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If you use weeds, it can take twice as much anesthesia



Image: Ethan Miller (Getty Images)

Like all drugs we use, there are good and bad effects that with cannabis. However, the new Monday study shows that one of these bad side effects can be strange tolerance to anesthesia. She found that people in Colorado who regularly use cannabis had twice as many powerful sedatives before the procedure

Colorado researchers researched 250 patients who had endoscopy, medical records, and procedures associated with sending the camera down to the throat (or other sensitive openings). ) to look at the body. They were specifically looking for patients after 201

2 because of the legalization of cannabis use in the country. Although until 2014 It would not be officially sold in stores, patients should still be more comfortable telling their doctors about cannabis use since 2012.

Those who said they used cannabis daily or weekly have found that they are less susceptible to several different classes of drugs used to soothe people compared to people who said they never used them. On average, 14 percent were needed. More fentanyl (opioids), 20 percent More midazolam (benzodiazepine) and 220 percent their procedures (endoscopy is usually performed with weak sedation, although some people need it or are chosen for deep sedation).

The results were published in the American Association of Osteopathy

. an osteopathic internal medicine physician has anecdotal evidence that patients taking cannabis requiring more sedation are smaller. However, this is, of course, a small study (only 25 cannabis users have been reviewed), it seems to be the first to try to quantify how much a problem can be. Patients who need higher doses may be more dangerous because they may increase the likelihood of side effects depending on the medicine

"Some sedatives have dose-related side effects, which means a higher dose. there is a greater likelihood of problems, ”said Twardowski. "This is especially dangerous when respiratory depression is a known side effect."

It is less likely that cannabis can be caused by an increase in this sedative tolerance. Cannabis and drug-based drugs primarily interact with a unique network of nervous system receptors called the endocannabinoid system. This system plays an important role in all body functions, from the feeling of hunger to the perception of pain. However, other drugs, including opioids and benzodiazepine, also interact with these receptors. And there may be other ways in which weeds can cause these side effects.

"This research is really the first small step," Twardowski said. "We still do not understand the mechanism of higher dose requirements, which is important for finding better care solutions."

What the study clearly shows, like others, is that we still do a lot to know about the effects of cannabis on the body. In essence, this is the fault of federal law, according to which cannabis is classified as a medicinal product without a medical purpose, preventing and slowing down research. However, it is good that cannabis and cannabis-based products can make the lack of knowledge prevent us from detecting the consequences of using less cannabis.

Twardowski and his team hope to further investigate the link between cannabis and sedative tolerance (including its effects on deep sedation), and whether cannabis can also affect pain management under medical procedures.


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