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Scientists Create First 3D Printed Heart Using Patient Cells



Researchers from Tel Aviv University have successfully printed the world's first 3D heart, using patient cells and biological materials to "fully meet the immunological, cell, biochemical, and anatomical characteristics of the patient."

from human cells and patient-specific biological materials. In our process, these materials are biological materials, materials made from sugars and proteins that can be used to print complex tissue models in 3D, ”said chief investigator Tal Dvir. “People have managed to print the heart structure in the past, but not with cells or blood vessels. Our results show our potential for personal future tissue and organ replacement. ”

F, G) A printed heart in auxiliary bath. H) After extraction, the left and right ventricles were injected with red and blue paints to show the hollow chamber and the space between them. Intelligent Science

In describing its work in the field of intelligent science, the study team began using biopsies of fat tissues from abdominal structures known as omentum, both in humans and pigs. Tissue cellular material has been separated from those that have not been and have not been reprogrammed to become pluripotent stem cells, the "main cells" capable of producing cells from all three layers of the body that can produce cells or tissues in the body. The team then formed an extracellular matrix composed of collagen and glycoproteins into the hydrogel used as the "ink" for printing. The cells were mixed with the hydrogel and then differentiated into the heart or endothelial cells (those that coincide with the inner surface of the blood and lymph vessels) to create a patient-specific, blood-compatible, cardiovascular-compatible, and ultimately, heart-specific "local" patients materials

Although promised, the team quickly reminds us that their hearts are not yet ready for human transplantation.

"At this stage, our 3D heart is small. rabbit heart, "Dvir said. "But larger human hearts need the same technology."

For beginners, creating a human heart will take longer and will require billions of cells – not just millions. In addition, cherry-sized hearts do not necessarily behave like hearts and require scientists to develop and "train" them as human hearts and create a pump. Currently, cells can agree but do not work together

Nevertheless, development is a huge step forward for organ transplant progress. Heart disease is the leading cause of death in men and women in the US, and heart transplant is the only treatment for those with heart failure. Not only does the lack of donors require the development of new strategies, but also creating hearts that combine a unique patient's biological makeup can prevent the risk of rejection.

"The bio-compatibility of engineering materials is essential to eliminate the risk of implant rejection, which jeopardizes the success of such treatments," said Dvir. "Ideally, biomaterials should have the same biochemical, mechanical, and topographical characteristics of the patient's tissue. Here we can report a simple approach to 3D printed thick, vascular and perfused heart tissues that are fully in line with the immunological, cellular, biochemical, and anatomical characteristics of the patient."

Cells are separated and treated with individualized thermoreactive hydrogel. and endothelial cells before the capsule into the hydrogel to produce the bio-materials used for printing, then the bio-blanks are printed on the engineer's vascular patches and complex cell structures.

                                    


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